Magnesium and cognition: Higher dietary intake linked to better brain health during ageing - Australian study

The researchers say increased intake​ of magnesium-rich foods such as spinach and nuts could also help reduce the risk of dementia, which is the seventh biggest killer globally.

The study of more than 6,000 cognitively healthy participants based in the United Kingdom aged 40 to 73 found people who consume more than 550 milligrams of magnesium each day have a brain age that is approximately one year younger by the time they reach 55 compared with someone with a normal magnesium intake of about 350 milligrams a day.

“Our study shows a 41 per cent increase in magnesium intake could lead to less age-related brain shrinkage, which is associated with better cognitive function and lower risk or delayed onset of dementia in later life,”​ lead author and PhD researcher Khawlah Alateeq, from the ANU National Centre for Epidemiology and Population Health, said.

“This research highlights the potential benefits of a diet high in magnesium and the role it plays in promoting good brain health.”​

It’s believed the number of people worldwide who will be diagnosed with dementia is expected to more than double from 57.4 million in 2019 to 152.8 million in 2050, placing a greater strain on health and social services and the global economy.

Prevention key

“Since there is no cure for dementia and the development of pharmacological treatments have been unsuccessful for the past 30 years, it’s been suggested that greater attention should be directed towards prevention,” study co-author Dr Erin Walsh, who is also from ANU, said.​

“Our research could inform the development of public health interventions aimed at promoting healthy brain ageing through dietary strategies.”​

The researchers say a higher intake of magnesium in diets from a younger age may safeguard against neurodegenerative diseases and cognitive decline by the time people hit their 40s.

“The study shows higher dietary magnesium intake may contribute to neuroprotection earlier in the ageing process and preventative effects may begin in our 40s or even earlier,”​ Ms Alateeq said.

“We also found the neuroprotective effects of more dietary magnesium appears to benefit women more than men and more so in post-menopausal than pre-menopausal women, although this may be due to the anti-inflammatory effect of magnesium.”​

Participants completed an online questionnaire five times over a period of 16 months. The responses provided were used to calculate the daily magnesium intake of participants and were based on 200 different foods with varying portion sizes. The ANU team focused on magnesium-rich foods such as leafy green vegetables, legumes, nuts, seeds and wholegrains to provide an average estimation of magnesium intake from the participants’ diets.

The paper concluded: "In summary, this study provides new evidence that higher dietary magnesium intake is related to better brain health in the general population. Since dietary advice and supplementation are easily scalable further research on the benefits of dietary magnesium needs to be conducted to provide the necessary evidence base to support possible population health interventions aimed at mitigating age-related neurodegeneration."​

Source: European Journal of Nutrition​​.​

"Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences"

https://doi.org/10.1007/s00394-023-03123-x

Authors: Khawlah Alateeq, et al​